Taub Institute: Genomics Core
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TaubCONNECT Research Perspectives:
2017 Archive

December 2017:

Neuronal Hyperactivity Due to Loss of Inhibitory Tone in APOE4 Mice Lacking Alzheimer's Disease-Like Pathology
The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

The Historical Progression from ADL Scrutiny to IADL to Advanced ADL: Assessing Functional Status in the Earliest Stages of Dementia

November 2017:

First Place: A CSF Proteomic Screen Links Retromer to Alzheimer's Pathogenic Pathways and Suggests Endosomal-Trafficking Biomarkers

First Place: Microglia Identity in the Aged and AD Human Brain

October 2017:

Intra-Axonal Synthesis of SNAP25 is Required for the Formation of Presynaptic Terminals

Increased Localization of APP-C99 in Mitochondria-associated ER Membranes Causes Mitochondrial Dysfunction in Alzheimer Disease

September 2017:

Stabilization of Dynamic Microtubules by mDia1 Drives Tau-dependent Aβ1-42 Synaptotoxicity

An xQTL Map Integrates the Genetic Architecture of the Human Brain's Transcriptome and Epigenome

August 2017:

Abolishing Tau Cleavage by Caspases at Aspartate421 Causes Memory/Synaptic Plasticity Deficits and Pre-Pathological Tau Alterations

Mediterranean Diet and Cognitive Health: Initial Results from the Hellenic Longitudinal Investigation of Ageing and Diet (HELIAD)

July 2017:

Abnormal Neurofilament Inclusions and Segregations in Dorsal Root Ganglia of A Charcot-Marie-Tooth Type 2E Mouse Model

LTP and Memory Impairment Caused by Extracellular Aβ and Tau Oligomers is APP-Dependent

June 2017:

Post translational Remodeling of Ryanodine Receptor Induces Calcium Leak Leading to Alzheimer's Disease like Pathologies and Cognitive Deficits

Neuropathologic Features of TOMM40 '523 Variant on Late-Life Cognitive Decline

May 2017:

Memory-Enhancing Effects of GEBR-32a, a New PDE4D Inhibitor Holding Promise for the Treatment of Alzheimer's Disease

An Approach to Studying the Neural Correlates of Reserve

April 2017:

Brain Atrophy Can Introduce Age-Related Differences in BOLD Response

Age-Related Biomarkers in LLFS Families With Exceptional Cognitive Abilities

March 2017:

Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes

Polygenic Risk Scores in Familial Alzheimer Diseases

February 2017:

Local Synthesis of Dynein Cofactors Matches Retrograde Transport to Acutely Changing Demands

Association of Obstructive Sleep Apnea with Episodic Memory and Cerebral Microvascular Pathology: A Preliminary Study

January 2017:

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease

Novel Genetic Loci Underlying Human Intracranial Volume Identified Through Genome-Wide Association

Relation of Dysglycemia to Structural Brain Changes in a Multiethnic Elderly Cohort

December 2016:

Unbiased Drug Screening Identified New Cellular Pathways that Regulate Apolipoprotein E Secretion in Human Primary Astrocytes

Prediction of Relapse After Discontinuation of Antipsychotic Treatment in Alzheimer's Disease: The Role of Hallucinations

November 2016:

Activating Transcription Factor 4 (ATF4) Modulates Rho GTPase Levels and Function via Regulation of RhoGDIα

Brain Regions Involved in Arousal and Reward Processing are Associated with Apathy in Alzheimer's Disease and Frontotemporal Dementia

October 2016:

First Place: White Matter Changes in Alzheimer's Disease

First Place: Understanding the Role of Phosphoinositide Dysregulation in Endolysosomal Dysfunction: Implications for Alzheimer's Disease

September 2016:

Time-Dependent Reversal of Synaptic Plasticity Induced by Physiological Concentrations of Oligomeric Aβ42: An Early Index of Alzheimer's Disease

Evidence that COMT Genotype and Proline Interact on Negative-Symptom Outcomes in Schizophrenia and Bipolar Disorder

August 2016:

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

LRRK2 and RAB7L1 Coordinately Regulate Axonal Morphology and Lysosome Integrity in Diverse Cellular Contexts

July 2016:

Alzheimer's Association International Conference (AAIC 2016)

June 2016:

Neuronal Activity Enhances Tau Propagation and Tau Pathology in Vivo

Sleep Disordered Breathing and White Matter Hyperintensities in Community-Dwelling Elders

May 2016:

White Matter Integrity as a Mediator in the Relationship between Dietary Nutrients and Cognition in the Elderly

Dementia Risk and Protective Factors Differ in the Context of Memory Trajectory Groups

April 2016:

White Matter Hyperintensities are a Core Feature of Alzheimer's Disease: Evidence From the Dominantly Inherited Alzheimer Network

Parkinson's Disease: Guilt by Genetic Association

March 2016:

PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease

PP2A Methylation Controls Sensitivity and Resistance to β-Amyloid–Induced Cognitive and Electrophysiological Impairments

February 2016:

Tau-driven 26S Proteasome Impairment and Cognitive Dysfunction can be Prevented Early in Disease by Activating cAMP-PKA Signaling

Older Adults with Poor Self-rated Memory have less Depressive Symptoms and Better Memory Performance when Perceived Self-efficacy is High

January 2016:

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

Examining the Pathways Between Self-Awareness and Well-Being in Mild to Moderate Alzheimer Disease

Mediterranean Diet and Brain Structure in a Multiethnic Elderly Cohort

December 2015:

Progression of Extrapyramidal Signs in Alzheimer's Disease: Clinical and Neuropathological Correlates

Telomere Longitudinal Shortening as a Biomarker for Dementia Status of Adults With Down Syndrome

November 2015:

The Reference Ability Neural Network Study: Life-time stability of reference-ability neural networks derived from task maps of young adults

Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease

October 2015:

First Place: DREADDs Activation in the Medial Entorhinal Cortex (MEC) of EC-Tau Mice

First Place: Amyloid Precursor Protein (APP) is Ubiquitinated at Multiple Sites in the COOH-Terminal Domain as a Signal for Endosomal Sorting

September 2015:

F-box/LRR-repeat Protein 7 is Genetically Associated with Alzheimer's Disease

The Keystone of Alzheimer Pathogenesis Might be Sought in Aβ Physiology

August 2015:

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Brain Amyloid Deposition and Longitudinal Cognitive Decline in Nondemented Older Subjects: Results from a Multi-Ethnic Population

July 2015:

Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome

Gene-Wise Association of Variants in Four Lysosomal Storage Disorder Genes in Neuropathologically Confirmed Lewy Body Disease

June 2015:

SUMO1 Affects Synaptic Function, Spine Density and Memory

Connectivity and Circuitry in a Dish Versus in a Brain

May 2015:

Making Cognitive Latent Variables Manifest: Distinct Neural Networks For Fluid Reasoning And Processing Speed

Functional Network Mediates Age-related Differences in Reaction Time: a Replication and Extension Study

Self-Efficacy Buffers the Relationship between Educational Disadvantage and Executive Functioning

April 2015:

Specific Downregulation of Hippocampal ATF4 Reveals a Necessary Role in Synaptic Plasticity and Memory

Mediterranean Diet and Leukocyte Telomere Length in a Multi-ethnic Elderly Population

March 2015:

Cerebellum can serve as a pseudo-reference region in Alzheimer's disease to detect neuroinflammation measured with PET radioligand binding to translocator protein (TSPO)

Assembly and Interrogation of Alzheimer's Disease Genetic Networks Reveal Novel Regulators of Progression

February 2015:

Neurotherapeutics: Rethinking Alzheimer's Disease Therapies

January 2015:

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

Olfactory deficits predict cognitive decline and Alzheimer dementia in an urban community

Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar

December 2014:

Regulation of Synaptic Plasticity and Cognition by SUMO in Normal Physiology and Alzheimer's Disease

Lobar Microbleeds are Associated with a Decline in Executive Functioning in Older Adults

November 2014:

Targeting Axonal Protein Synthesis in Neuroregeneration and Degeneration

Inbreeding Among Caribbean Hispanics from the Dominican Republic and its Effects on Risk of Alzheimer Disease

Coding Mutations in SORL1 and Alzheimer's Disease

October 2014:

First Place: Pathogenic Role of Formin-mediated Stable Detyrosinated Microtubule Inductionby Amyloid Beta

First Place: Differential Responsiveness to Entorhinal Cortical Input Distinguishes CA1 Pyramidal Neuron Subpopulations

September 2014:

Soluble Amyloid Beta Levels are Elevated in the White Matter of Alzheimer's Patients, Independent of Cortical Plaque Severity

A Time Course Analysis of the Electrophysiological Properties of Neurons Differentiated from Human Induced Pluripotent Stem Cells (iPSCs)

August 2014:

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal Across Brain Regions

July 2014:

Olfactory Dysfunction in the Elderly: Basic Circuitry and Alterations with Normal Aging and Alzheimer's Disease

June 2014:

Neurological Disorders: Quality-control Pathway Unlocked

May 2014:

Estrogen Receptor β Variants Modify Risk for Alzheimer's Disease in a Multiethnic Female Cohort

April 2014:

Combined Suppression of CASP2 and CASP6 Protects Retinal Ganglion Cells from Apoptosis and Promotes Axon Regeneration Through CNTF-mediated JAK/STAT Signalling and Guidelines

Local Synthesis of TC10 is Required for Membrane Expansion During Axon Outgrowth

March 2014:

Dynamin 1 is Required for Memory Formation

February 2014:

Behavioral Assays with Mouse Models of Alzheimer's Disease: Practical Considerations and Guidelines

January 2014:

Biobanked Alzheimer's Brain Tissue Yields Living Neurons

Picomolar Amyloid-ß Peptides Enhance Spontaneous Astrocyte Calcium Transients

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