Taub Institute: Genomics Core


Columbia University
Irving Medical Center
Neurological Institute

710 West 168th Street, 3rd floor
(212) 305-1818

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About Us

Taub Faculty

Ulrich Hengst, PhD

Ulrich Hengst, PhD

Professor of Pathology and Cell Biology (in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain)

Email: uh2112@cumc.columbia.edu
Tel: (212) 305-9334
Fax: (646) 426-0059

Local protein synthesis in developing and degenerating neurons.

Neurons are arguable the cells with the most extreme morphological polarization, with distances between the periphery and the neuronal cell bodies ranging from millimeters to several feet. This extreme architectural polarization is mirrored in the existence of functionally distinct subcellular compartments, chiefly dendrites, axon, and soma. Spatially restricted protein expression is crucial for the establishment and maintenance of polarized neuronal morphology and function. Indeed, it has become apparent that alterations of polarized protein expression can cause or contribute to the pathogenesis of a wide variety of disorders. Our laboratory studies the physiological role of intra-axonal translation during development as well as the possible role of local protein synthesis during neurodegenerative disorders, especially Alzheimer's disease. We seek to understand how changes in local protein synthesis can either attenuate or ameliorate neuronal integrity in AD brain.

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