Taub Institute: Genomics Core
AN NIA-FUNDED ALZHEIMER'S DISEASE RESEARCH CENTER

 

Columbia University
Irving Medical Center
Neurological Institute

710 West 168th Street, 3rd floor
(212) 305-1818


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About Us

Taub Faculty

Ismael Santa-Maria Perez, PhD

Ismael Santa-Maria Perez, PhD

Assistant Professor of Pathology and Cell Biology
Taub Institute for Research on Alzheimer's Disease and the Aging Brain

Phone: 212-305-6371
Email: is2395@cumc.columbia.edu

Dr. Santa-Maria Perez is a biochemist with a Ph.D. in Molecular Biology. He heads a research laboratory investigating the role of microRNAs and post-transcriptional regulation in the onset and progression of neurodegenerative diseases.

Research

Research in our laboratory is focused on understanding the mechanisms maintaining or altering tau proteostasis in neurons, and their relevance in aging and Alzheimer's disease (AD). Intracellular accumulation of neurofibrillary tangles of hyperphosphorylated misfolded tau proteins is one of the main hallmarks in many neurodegenerative diseases, including AD. Little is known about the mechanisms underlying tau dysfunction and neurofibrillary degeneration but a dysfunctional regulation of protein expression has been proposed to participate in the pathogenesis of AD and related tauopathies. In addition, it is unclear whether disturbances in the levels of microRNAs or other molecules that directly regulate tau proteostasis contribute to the pathogenesis of AD. Hence, investigating how certain microRNAs impact tau synthesis, hyperphosphorylation and accumulation in the disease is currently the main interest of our laboratory. In our research, we employ a variety of biochemical, cell culture, transgenic animal (Drosophila and mice) and molecular biology techniques to approach all these questions.

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